South Preston is divided into three portions – East Lane Business Park north of East Lane, a suburban area connected to Wembley and around King Edward VII Park between East Lane to its north and the Chiltern Railways line to the south, and another suburban area connected to Tokyngton (or Monks Park) south of the railway line. The western boundary is the Overground and Bakerloo line, while the eastern boundary consists of Preston Road, Wembley Hill Road and Harrow Road. East Lane Business Park consists of many light industrial and warehousing buildings, along with some offices. Some of the units are gated, and there are car parks on site. The area is also in proximity to a number of low-rise flats along the Preston Road area. Meanwhile, the two suburban areas are largely congruent with the rest of Wembley – interwar semi-detached houses with a number of shops and pubs along their high streets. A small shopping district exists around Wembley Central, which sees the area’s only high-rises.

The area gradually developed when it was bought by John Gray, who built a manor house in the area in the early 1800s. What is today Wembley Central was built here in 1844, then named Sudbury. Another railway line – the Metropolitan Railway, would soon arrive in the 1870s, but did not have a stop in the area. When John Gray passed away with no heir, the estate was put up for sale, and the railway company bought the 114-hectare estate. The area would again diverge from its nearby neighbour Wembley Park when the latter gradually began to fill in with Metroland development spurred by the railways.

North Wembley, on the Bakerloo line, is the safest tube station on the network, according to the Metropolitan Police.

King Edward VII Park was opened on 4 July 1914, in memory of the late king as well as to replace the loss of nearby Wembley Park, after the latter had undergone vast suburban development as part of the Metroland schemes during the 30s.

Some residents have noted problems around King Edward VII Park, such as anti- social drinking behaviour, even when the park is supposedly locked at night. Other anti-social behaviours, such as drug use, have also been reported, though this is largely confined to the park itself.

As nearby Wembley Park grows, with thousands of new homes expected to be added to an already dizzying array of modern apartments, the area around Preston Road is undergoing its own regeneration. Arc at Wembley is one such example, comprising a total of 144 new apartments, 75 of which will be protected under the shared ownership scheme, and 15 of which will be London Living Rent homes. Expected to complete early in 2023 this project will be located on the corner of South Way and Wembley Hill Road. Further in the future, the vast North East Lands is expected to take up significant space between this neighbourhood and Wembley Park, claiming to be able to provide over 2000 new homes when completed in 2027.